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    OAF1 oleate-activated transcription factor OAF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851247, updated on 14-Nov-2024

    Summary

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    Official Symbol
    OAF1
    Official Full Name
    oleate-activated transcription factor OAF1
    Primary source
    SGD:S000000048
    Locus tag
    YAL051W
    See related
    AllianceGenome:SGD:S000000048; FungiDB:YAL051W; VEuPathDB:YAL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAF1
    Summary
    Enables sequence-specific DNA binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to oleic acid; positive regulation of fatty acid beta-oxidation; and positive regulation of transcription from RNA polymerase II promoter by oleic acid. Part of Pip2-Oaf1 complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See OAF1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (48564..51707)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene acetate--CoA ligase 1 Neighboring gene flavin adenine dinucleotide transporter FLC2 Neighboring gene protein AIM2 Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. Luo Y, et al. J Biol Chem, 1996 May 17. PMID 8662598
    2. Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Rottensteiner H, et al. Eur J Biochem, 2003 May. PMID 12709061
    3. Fungi and animals may share a common ancestor to nuclear receptors. Phelps C, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16636289, Free PMC Article
    4. Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p. Different roles in fatty acid induction of beta-oxidation in Saccharomyces cerevisiae. Baumgartner U, et al. J Biol Chem, 1999 Aug 6. PMID 10428786
    5. Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources. Kal AJ, et al. Mol Biol Cell, 1999 Jun. PMID 10359602, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The OAF1 and OLE1 variants showed a non-additive genetic interaction, and affected cellular lipid metabolism. These results demonstrate that the molecular basis of trans-regulatory variation is diverse, highlighting the challenges in predicting which natural genetic variants affect gene expression
      Title: DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories.
    2. Data indicate that Oaf1p, Pip2p and Adr1p are required for the initial binding of Oaf3p before oleate induction.
      Title: Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response.
    3. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p.
      Title: Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p.
    4. Oaf1 may form homodimers which apparently substitute for the Oaf1-Pip2 heterodimer.
      Title: Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oleic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Pip2-Oaf1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Pip2-Oaf1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oleate-activated transcription factor OAF1
    NP_009349.3
    • Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      48564..51707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178195.2 → NP_009349.3  TPA: oleate-activated transcription factor OAF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009349.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG6, P39720
      UniProtKB/TrEMBL
      B3LUY6, C8Z3G1
      Conserved Domains (2) summary
      cd12148
      Location:338 → 784
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      pfam00172
      Location:64 → 100
      Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39720.3

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