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    GPB2 Gpb2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851243, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPB2
    Official Full Name
    Gpb2p
    Primary source
    SGD:S000000052
    Locus tag
    YAL056W
    See related
    AllianceGenome:SGD:S000000052; FungiDB:YAL056W; VEuPathDB:YAL056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KRH1
    Summary
    Enables GTPase activating protein binding activity and cAMP-dependent protein kinase inhibitor activity. Involved in several processes, including invasive growth in response to glucose limitation; negative regulation of Ras protein signal transduction; and pseudohyphal growth. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPB2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (39259..41901)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Ecm1p Neighboring gene calnexin Neighboring gene ubiquitin-protein transferase activating protein PEX22 Neighboring gene acetate--CoA ligase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. Batlle M, et al. J Cell Sci, 2003 Feb 15. PMID 12538771
    2. Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation. Aggeli D, et al. Nat Commun, 2021 Aug 31. PMID 34465770, Free PMC Article
    3. Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. Niranjan T, et al. J Biol Chem, 2007 Aug 17. PMID 17584745
    4. Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation. Kinsler G, et al. Elife, 2020 Dec 2. PMID 33263280, Free PMC Article
    5. KRH1 and KRH2 are functionally non-redundant in signaling for pseudohyphal differentiation in Saccharomyces cerevisiae. Iyer RS, et al. Curr Genet, 2017 Oct. PMID 28247024

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpb1 and Gpb2 oppose PKA activity by blocking the ability of PKA to inhibit Bcy1 phosphorylation
      Title: Nutrient control of yeast PKA activity involves opposing effects on phosphorylation of the Bcy1 regulatory subunit.
    2. Gpa2 relieves the inhibition imposed by the kelch-repeat proteins on Protein Kinase A (PKA), thereby bypassing adenylate cyclase for direct regulation of PKA.
      Title: Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.
    3. Gpb1/2 bind to a conserved C-terminal domain of Ira1/2, and loss of Gpb1/2 results in a destabilization of Ira1 and Ira2, leading to elevated levels of Ras2-GTP and unbridled cAMP-PKA signaling.
      Title: The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation HMP PubMed 
    involved_in glucose mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glucose mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gpb2p
    NP_009345.3
    • Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      39259..41901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178199.2 → NP_009345.3  TPA: Gpb2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009345.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG2, P39716, P39717
      UniProtKB/TrEMBL
      G2W8H6
      Conserved Domains (1) summary
      pfam13854
      Location:278 → 316
      Kelch_5; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39717.4

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