MLG1 putative acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MLG1
Official Full Name: putative acyltransferase
Primary source: SGD:S000002425
Locus tag: YDR018C
See related: AllianceGenome:SGD:S000002425; FungiDB:YDR018C; VEuPathDB:YDR018C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables lysophosphatidic acid acyltransferase activity. Involved in phosphatidic acid biosynthetic process. Acts upstream of or within phosphatidylethanolamine acyl-chain remodeling and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum and nucleus. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to several human genes including AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphatidylethanolamine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylserine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_010301.1

Lysolipid acyltransferase; involved in the synthesis of phosphatidic acid from 1-acyl-2-hydroxy-sn-glycero-3-phosphate using oleoyl-CoA as acyl donor and in phospholipid remodeling, incorporating palmitic acid into the sn-1 position of phosphatidylserine and phosphatidylethanolamine; localizes to ER membranes associated with mitochondria (MAMs); contains three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase

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