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    MRX19 Mrx19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851345, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MRX19
    Official Full Name
    Mrx19p
    Primary source
    SGD:S000002342
    Locus tag
    YDL183C
    See related
    AllianceGenome:SGD:S000002342; FungiDB:YDL183C; VEuPathDB:YDL183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in potassium ion transport and proton transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MRX19 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (130871..131833, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit A Neighboring gene ribosomal 60S subunit protein L41A Neighboring gene homocitrate synthase LYS20 Neighboring gene ATPase inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel components of an active mitochondrial K(+)/H(+) exchange. Zotova L, et al. J Biol Chem, 2010 May 7. PMID 20197279, Free PMC Article
    2. Disruption of 12 ORFs located on chromosomes IV, VII and XIV of Saccharomyces cerevisiae reveals two essential genes. Volckaert G, et al. Yeast, 2003 Jan 15. PMID 12489128
    3. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643
    4. Mapping pathways and phenotypes by systematic gene overexpression. Sopko R, et al. Mol Cell, 2006 Feb 3. PMID 16455487
    5. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mrx19p
    NP_010098.1
    • Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      130871..131833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180243.1 → NP_010098.1  TPA: Mrx19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010098.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRG9, P48569
      UniProtKB/TrEMBL
      A6ZXE8, B3LH67, B5VF90, C7GUM2, C8Z6C1, G2WBY2, N1P5E0
      Conserved Domains (1) summary
      pfam10173
      Location:46 → 241
      Mit_KHE1; Mitochondrial K+-H+ exchange-related
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48569.1

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