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    TMA64 Tma64p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851695, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMA64
    Official Full Name
    Tma64p
    Primary source
    SGD:S000002524
    Locus tag
    YDR117C
    See related
    AllianceGenome:SGD:S000002524; FungiDB:YDR117C; VEuPathDB:YDR117C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in rRNA processing. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TMA64 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (683946..685643, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative mitochondrial 54S ribosomal protein Neighboring gene mitochondrial 54S ribosomal protein MRPL1 Neighboring gene anaphase promoting complex subunit 4 Neighboring gene Vba4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Translatome and transcriptome analysis of TMA20 (MCT-1) and TMA64 (eIF2D) knockout yeast strains. Makeeva DS, et al. Data Brief, 2019 Apr. PMID 30815525, Free PMC Article
    2. Differential effects of 40S ribosome recycling factors on reinitiation at regulatory uORFs in GCN4 mRNA are not dictated by their roles in bulk 40S recycling. Jendruchová K, et al. Commun Biol, 2024 Sep 4. PMID 39232119, Free PMC Article
    3. GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. Dmitriev SE, et al. J Biol Chem, 2010 Aug 27. PMID 20566627, Free PMC Article
    4. 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling. Young DJ, et al. Nat Commun, 2021 May 20. PMID 34016977, Free PMC Article
    5. Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs. Gaikwad S, et al. Elife, 2021 Mar 25. PMID 33764298, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
      Title: 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Tma64p
    NP_010402.3
    • hypothetical protein that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      683946..685643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180425.3 → NP_010402.3  TPA: Tma64p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010402.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA2, Q04600
      UniProtKB/TrEMBL
      B3LGG0, B5VG12, N1PAD6
      Conserved Domains (3) summary
      cd11608
      Location:474 → 556
      eIF2D_C; C-terminal domain of eIF2D and related proteins
      pfam17832
      Location:2 → 86
      Pre-PUA; Pre-PUA-like domain
      cd21156
      Location:88 → 170
      PUA_eIF2d-like; PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04600.1

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