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    PTI1 cleavage polyadenylation factor subunit PTI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853060, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PTI1
    Official Full Name
    cleavage polyadenylation factor subunit PTI1
    Primary source
    SGD:S000003388
    Locus tag
    YGR156W
    See related
    AllianceGenome:SGD:S000003388; FungiDB:YGR156W; VEuPathDB:YGR156W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Predicted to contribute to RNA binding activity. Involved in mRNA processing; sno(s)RNA 3'-end processing; and termination of RNA polymerase II transcription, exosome-dependent. Located in cytosol and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PTI1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (800546..801823)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene omega-class glutathione transferase Neighboring gene cystathionine beta-synthase CYS4 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene exosome non-catalytic core subunit MTR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. Dheur S, et al. EMBO J, 2003 Jun 2. PMID 12773397, Free PMC Article
    2. The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Skaar DA, et al. Mol Cell, 2002 Dec. PMID 12504017
    3. Regulation of yeast mRNA 3' end processing by phosphorylation. He X, et al. Mol Cell, 2005 Sep 2. PMID 16137619
    4. The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing. Ghazy MA, et al. Mol Cell Biol, 2009 Apr. PMID 19188448, Free PMC Article
    5. Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing. Kumar A, et al. Genes Dev, 2021 Nov 1. PMID 34593603, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase II transcription, exosome-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage polyadenylation factor subunit PTI1
    NP_011672.1
    • Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      800546..801823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181285.1 → NP_011672.1  TPA: cleavage polyadenylation factor subunit PTI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUT6, P39927
      UniProtKB/TrEMBL
      A6ZUG7, B3LI74, B5VJ99, C7GQ64, C8Z950, G2WEN6, N1P3T5
      Conserved Domains (3) summary
      TIGR01628
      Location:306 → 413
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00360
      Location:21 → 90
      RRM; RNA recognition motif
      pfam14327
      Location:185 → 255
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39927.2

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