YCG1 condensin subunit YCG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YCG1
Official Full Name: condensin subunit YCG1
Primary source: SGD:S000002733
Locus tag: YDR325W
See related: AllianceGenome:SGD:S000002733; FungiDB:YDR325W; VEuPathDB:YDR325W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TIE1; YCS5
Summary: Enables chromatin binding activity. Involved in chromosome organization; meiotic chromosome separation; and negative regulation of meiotic DNA double-strand break formation. Part of condensin complex. Orthologous to human NCAPG (non-SMC condensin I complex subunit G). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YCG1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1117126..1120233)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Title: Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Together, these results demonstrate that Ycg1 levels limit condensin function in interphase cells, and suggest that the association of condensin with chromosomes must be reduced following mitosis to enable efficient progression through the cell cycle.
Title: Levels of Ycg1 Limit Condensin Function during the Cell Cycle.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in meiotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic DNA double-strand break formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA gene clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: condensin subunit YCG1

NP_010612.2

Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1117126..1120233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180633.1 → NP_010612.2 TPA: condensin subunit YCG1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010612.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSV8, Q06680

UniProtKB/TrEMBL

A6ZYS8, B3LFX1, C7GWM4, C8Z5N8, G2WB65, N1P765

Conserved Domains (2) summary

COG5218
Location:5 → 1033

YCG1; Chromosome condensation complex Condensin, subunit G [Chromatin structure and dynamics / Cell division and chromosome partitioning]

sd00044
Location:118 → 146

HEAT; HEAT repeat [structural motif]