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    CBP4 Cbp4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CBP4
    Official Full Name
    Cbp4p
    Primary source
    SGD:S000003406
    Locus tag
    YGR174C
    See related
    AllianceGenome:SGD:S000003406; FungiDB:YGR174C; VEuPathDB:YGR174C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CBP4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (845893..846405, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rbg2p Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein Neighboring gene squalene monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of CBP4, a new gene essential for the expression of ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae. Crivellone MD. J Biol Chem, 1994 Aug 19. PMID 8063753
    2. A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria. Heinemeyer J, et al. J Biol Chem, 2007 Apr 20. PMID 17322303
    3. Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1) complex assembly in Saccharomyces cerevisiae. Kronekova Z, et al. Curr Genet, 2005 Apr. PMID 15759116
    4. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, et al. J Cell Biol, 2011 Jun 13. PMID 21670217, Free PMC Article
    5. Timing of dimerization of the bc(1) complex during mitochondrial respiratory chain assembly. Stephan K, et al. Biochim Biophys Acta Bioenerg, 2020 Jun 1. PMID 32119834

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cbp3p and Cbp4p are two mitochondrial proteins which are postulated to act as chaperones in bc(1) complex formation.
      Title: Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1) complex assembly in Saccharomyces cerevisiae.
    2. model of the cytochrome C reductase/oxidase supercomplex from Saccharomyces mitochondria
      Title: A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cbp4p
    NP_011690.3
    • Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      845893..846405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181303.3 → NP_011690.3  TPA: Cbp4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011690.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2WEQ5, N1P608
      Conserved Domains (1) summary
      pfam07960
      Location:28 → 151
      CBP4
    Nucleotide Protein
    Heading Accession and Version

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