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    SNT1 Snt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNT1
    Official Full Name
    Snt1p
    Primary source
    SGD:S000000629
    Locus tag
    YCR033W
    See related
    AllianceGenome:SGD:S000000629; FungiDB:YCR033W; VEuPathDB:YCR033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Involved in positive regulation of stress-activated MAPK cascade and regulation of DNA-templated transcription. Located in cytosol and nucleus. Part of Set3 complex. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR1 (nuclear receptor corepressor 1) and NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNT1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (186489..190169)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Bph1p Neighboring gene fatty acid elongase ELO2 Neighboring gene exosome non-catalytic core subunit RRP43

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex. Cerna D, et al. J Mol Biol, 2005 Aug 26. PMID 16051270
    2. A Prion Epigenetic Switch Establishes an Active Chromatin State. Harvey ZH, et al. Cell, 2020 Mar 5. PMID 32109413, Free PMC Article
    3. Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. La Ferla M, et al. Mutat Res, 2015 Apr. PMID 25779917
    4. Structural and functional analysis of the SET3 histone deacetylase complex. Reyes AA, et al. Acta Crystallogr F Struct Biol Commun, 2022 Mar 1. PMID 35234136, Free PMC Article
    5. Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Arévalo-Rodríguez M, et al. Eukaryot Cell, 2005 Jan. PMID 15643056, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Prion Epigenetic Switch Establishes an Active Chromatin State.
      Title: A Prion Epigenetic Switch Establishes an Active Chromatin State.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of Set3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snt1p
    NP_009962.2
    • Set3C histone deacetylase scaffold; can act as prion [ESI+] (Expressed Subtelomeric Information) that drives emergence and transgenerational inheritance of activated chromatin state; prion conformer is triggered by transient Snt1p phosphorylation upon cell cycle arrest; [ESI+] reshapes the activity Set3C, recruiting RNAPII, interfering with Rap1p binding to activate genes in otherwise repressed subtelomeric domains; relocalizes to cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      186489..190169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178747.1 → NP_009962.2  TPA: Snt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009962.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR43, P25357, Q02397, Q8NIL8
      UniProtKB/TrEMBL
      C8Z4C3, N1P849
      Conserved Domains (5) summary
      PHA03255
      Location:62 → 173
      PHA03255; BDLF3; Provisional
      COG5116
      Location:715 → 803
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      PRK03918
      Location:348 → 588
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00167
      Location:672 → 716
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:892 → 933
      Myb_DNA-binding; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25357.2

    Gene LinkOut

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