U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RTN2 Rtn2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851323, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RTN2
    Official Full Name
    Rtn2p
    Primary source
    SGD:S000002363
    Locus tag
    YDL204W
    See related
    AllianceGenome:SGD:S000002363; FungiDB:YDL204W; VEuPathDB:YDL204W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ER-dependent peroxisome organization; endoplasmic reticulum organization; and response to endoplasmic reticulum stress. Located in cortical endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RTN2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (94605..95786)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene uncharacterized protein Neighboring gene Ack1p Neighboring gene mitochondrial 54S ribosomal protein YmL11

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae. Okamoto M, et al. J Cell Sci, 2012 Jul 15. PMID 22467862
    2. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. West M, et al. J Cell Biol, 2011 Apr 18. PMID 21502358, Free PMC Article
    3. Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function. Diaz A, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805477, Free PMC Article
    4. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. Shibata Y, et al. J Biol Chem, 2008 Jul 4. PMID 18442980, Free PMC Article
    5. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Hu J, et al. Science, 2008 Feb 29. PMID 18309084

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rtn2p
    NP_010077.1
    • Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      94605..95786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180264.1 → NP_010077.1  TPA: Rtn2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF0, Q12443
      UniProtKB/TrEMBL
      B3LH84, C7GV65, G2WBW3, N1PAF0
      Conserved Domains (1) summary
      pfam02453
      Location:33 → 188
      Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12443.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools