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    RFC4 replication factor C subunit 4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854059, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RFC4
    Official Full Name
    replication factor C subunit 4
    Primary source
    SGD:S000005454
    Locus tag
    YOL094C
    See related
    AllianceGenome:SGD:S000005454; FungiDB:YOL094C; VEuPathDB:YOL094C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA clamp loader activity. Involved in leading strand elongation and sister chromatid cohesion. Located in cytosol and nucleus. Part of chromosome. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RFC4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (141584..142555, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene tRNA (guanine(9)-N(1))-methyltransferase Neighboring gene cationic amino acid transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon. Burgers PM. J Biol Chem, 1991 Nov 25. PMID 1682322
    2. The N- and C-termini of Elg1 contribute to the maintenance of genome stability. Davidson MB, et al. DNA Repair (Amst), 2008 Aug 2. PMID 18482875
    3. Cloning and characterization of the essential Saccharomyces cerevisiae RFC4 gene encoding the 37-kDa subunit of replication factor C. Li X, et al. J Biol Chem, 1994 Aug 26. PMID 8063832
    4. Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering. Dong C, et al. Metab Eng, 2021 Jul. PMID 33713797
    5. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim HS, et al. Mol Cell Biol, 2001 Jun. PMID 11340166, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Elg1 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Elg1 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Elg1 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad17 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 4
    NP_014547.1
    • Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      141584..142555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183348.1 → NP_014547.1  TPA: replication factor C subunit 4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X4, P40339
      UniProtKB/TrEMBL
      A6ZNB6, B3LIW9, B5VRG1, C7GRU7, C8ZHM1, G2WME1, N1NXM2
      Conserved Domains (1) summary
      PLN03025
      Location:9 → 323
      PLN03025; replication factor C subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40339.1

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