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    PGC1 phosphatidylglycerol phospholipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGC1
    Official Full Name
    phosphatidylglycerol phospholipase
    Primary source
    SGD:S000006127
    Locus tag
    YPL206C
    See related
    AllianceGenome:SGD:S000006127; FungiDB:YPL206C; VEuPathDB:YPL206C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylglycerol phospholipase C activity. Involved in phosphatidylglycerol catabolic process. Located in lipid droplet and mitochondrion. Orthologous to human GDPD1 (glycerophosphodiester phosphodiesterase domain containing 1) and GDPD3 (glycerophosphodiester phosphodiesterase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (162632..163597, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene putative tRNA 4-demethylwyosine synthase Neighboring gene serine/threonine protein kinase HRR25 Neighboring gene cAMP-dependent protein kinase catalytic subunit TPK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism. Simocková M, et al. J Biol Chem, 2008 Jun 20. PMID 18434318, Free PMC Article
    2. Two Different Phospholipases C, Isc1 and Pgc1, Cooperate To Regulate Mitochondrial Function. Balazova M, et al. Microbiol Spectr, 2022 Dec 21. PMID 36377885, Free PMC Article
    3. Blocking phosphatidylglycerol degradation in yeast defective in cardiolipin remodeling results in a new model of the Barth syndrome cellular phenotype. Káňovičová P, et al. J Biol Chem, 2022 Jan. PMID 34864056, Free PMC Article
    4. Specific degradation of phosphatidylglycerol is necessary for proper mitochondrial morphology and function. Pokorná L, et al. Biochim Biophys Acta, 2016 Jan. PMID 26482708, Free PMC Article
    5. Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae. Fisher E, et al. J Biol Chem, 2005 Oct 28. PMID 16141200

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Different Phospholipases C, Isc1 and Pgc1, Cooperate To Regulate Mitochondrial Function.
      Title: Two Different Phospholipases C, Isc1 and Pgc1, Cooperate To Regulate Mitochondrial Function.
    2. Pgc1p is required for the removal of excess PG via a phospholipase C-type degradation mechanism
      Title: Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism.
    3. in contrast to ypl206c, ypl110c does not use GroPCho for growth
      Title: Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylglycerol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylglycerol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylglycerol phospholipase C activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylglycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylglycerol phospholipase
    NP_015118.1
    • Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      162632..163597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184020.1 → NP_015118.1  TPA: phosphatidylglycerol phospholipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3G4, Q08959
      UniProtKB/TrEMBL
      A6ZW49, B3LKM4, C7GN33, C8ZIH3, G2WNX9, N1NXY9
      Conserved Domains (1) summary
      cd08570
      Location:4 → 244
      GDPD_YPL206cp_fungi; Glycerophosphodiester phosphodiesterase domain of Saccharomyces cerevisiae YPL206cp and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08959.1

    Gene LinkOut

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