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    SRP72 signal recognition particle subunit SRP72 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRP72
    Official Full Name
    signal recognition particle subunit SRP72
    Primary source
    SGD:S000006131
    Locus tag
    YPL210C
    See related
    AllianceGenome:SGD:S000006131; FungiDB:YPL210C; VEuPathDB:YPL210C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRP72 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (154290..156212, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS1 Neighboring gene ribosome biosynthesis protein NIP7 Neighboring gene aurora kinase Neighboring gene protein-lysine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Does a deficiency of the signal recognition particle (SRP)-pathway affect the biosynthesis of its components in Saccharomyces cerevisiae and Escherichia coli? Kovalskaya ON, et al. Biochemistry (Mosc), 2006 Jul. PMID 16903826
    2. Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle. van Nues RW, et al. RNA Biol, 2008 Apr-Jun. PMID 18418087
    3. Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation. Dalley JA, et al. Mol Biol Cell, 2008 Jul. PMID 18448667, Free PMC Article
    4. Elongation arrest is a physiologically important function of signal recognition particle. Mason N, et al. EMBO J, 2000 Aug 1. PMID 10921896, Free PMC Article
    5. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway. Ciufo LF, et al. Curr Biol, 2000 Oct 19. PMID 11069106

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    contributes_to ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle subunit SRP72
    NP_015114.2
    • Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      154290..156212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184024.1 → NP_015114.2  TPA: signal recognition particle subunit SRP72 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015114.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3G0, P38688
      UniProtKB/TrEMBL
      A6ZW45, B3LKM0, C7GN37, C8ZIG9, N1NW93
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38688.2

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