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    SRB6 Srb6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852555, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SRB6
    Official Full Name
    Srb6p
    Primary source
    SGD:S000000457
    Locus tag
    YBR253W
    See related
    AllianceGenome:SGD:S000000457; FungiDB:YBR253W; VEuPathDB:YBR253W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED22
    Summary
    Predicted to enable transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SRB6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (723270..723635)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRPS5 Neighboring gene bifunctional dITP/dUTP diphosphatase Neighboring gene TRAPP subunit TRS20 Neighboring gene Mtc4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An RNA polymerase II holoenzyme responsive to activators. Koleske AJ, et al. Nature, 1994 Mar 31. PMID 8133894
    2. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo. Lee D, et al. Nature, 1998 May 28. PMID 9620805
    3. General requirement for RNA polymerase II holoenzymes in vivo. Thompson CM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753848, Free PMC Article
    4. An activator target in the RNA polymerase II holoenzyme. Koh SS, et al. Mol Cell, 1998 May. PMID 9660972
    5. Association of an activator with an RNA polymerase II holoenzyme. Hengartner CJ, et al. Genes Dev, 1995 Apr 15. PMID 7774808

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srb6p
    NP_009812.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      723270..723635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178601.1 → NP_009812.1  TPA: Srb6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQP9, P32570
      UniProtKB/TrEMBL
      A6ZLJ2, B3LMQ9, C7GMX8, D3UF00, G2W9Q6, N1P8K3
      Conserved Domains (1) summary
      pfam06179
      Location:8 → 117
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32570.1

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