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    SMC2 condensin subunit SMC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMC2
    Official Full Name
    condensin subunit SMC2
    Primary source
    SGD:S000001927
    Locus tag
    YFR031C
    See related
    AllianceGenome:SGD:S000001927; FungiDB:YFR031C; VEuPathDB:YFR031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP binding activity; DNA binding activity; and chromatin binding activity. Contributes to ATP hydrolysis activity. Involved in chromosome organization and negative regulation of meiotic DNA double-strand break formation. Located in mitochondrion. Part of condensin complex. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMC2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (216594..220106, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Ptr3p Neighboring gene sulfite reductase subunit alpha Neighboring gene ribosomal 60S subunit protein L2A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Condensin-Mediated Chromosome Folding and Internal Telomeres Drive Dicentric Severing by Cytokinesis. Guérin TM, et al. Mol Cell, 2019 Jul 11. PMID 31204167
    2. SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family. Strunnikov AV, et al. Genes Dev, 1995 Mar 1. PMID 7698648
    3. Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae. Eki T, et al. Yeast, 1996 Feb. PMID 8686379
    4. The yeast genome undergoes significant topological reorganization in quiescence. Rutledge MT, et al. Nucleic Acids Res, 2015 Sep 30. PMID 26202961, Free PMC Article
    5. Multiple roles of Condensins: a complex story. Legagneux V, et al. Biol Cell, 2004 Apr. PMID 15182703

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
      Title: Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
    2. S. cerevisiae Smc2-Smc4 dimers adopt a variety of conformations.
      Title: Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.
    3. Contribution of condensin binding sites in securing mitotic stability of the minichromosomes.
      Title: [Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model].
    4. Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling
      Title: The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling.
    5. The SMC2 is involved in several aspects of chromatin dynamics and DNA recombitional repair.
      Title: Multiple roles of Condensins: a complex story.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA secondary structure binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables minor groove of adenine-thymine-rich DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA chromatin condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA gene clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    condensin subunit SMC2
    NP_116687.1
    • Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      216594..220106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179996.2 → NP_116687.1  TPA: condensin subunit SMC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTR1, P38989
      UniProtKB/TrEMBL
      A7A268, B3LUN9, B5VI56, C7GYD4, N1P516
      Conserved Domains (1) summary
      COG1196
      Location:1 → 1169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38989.1

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