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    QCR6 ubiquinol--cytochrome-c reductase subunit 6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    QCR6
    Official Full Name
    ubiquinol--cytochrome-c reductase subunit 6
    Primary source
    SGD:S000001929
    Locus tag
    YFR033C
    See related
    AllianceGenome:SGD:S000001929; FungiDB:YFR033C; VEuPathDB:YFR033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COR3; UCR6
    Summary
    Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial intermembrane space and nuclear periphery. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRH (ubiquinol-cytochrome c reductase hinge protein) and UQCRHL (ubiquinol-cytochrome c reductase hinge protein like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See QCR6 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (224326..224769, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L29 Neighboring gene Min10p Neighboring gene phosphate-sensing transcription factor PHO4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The petite phenotype resulting from a truncated copy of subunit 6 results from loss of assembly of the cytochrome bc1 complex and can be suppressed by overexpression of subunit 9. Schmitt ME, et al. J Biol Chem, 1991 Aug 15. PMID 1651316
    2. Subunit 6 regulates half-of-the-sites reactivity of the dimeric cytochrome bc1 complex in Saccharomyces cerevisiae. Schmitt ME, et al. J Biol Chem, 1990 Oct 5. PMID 2170363
    3. The cleaved presequence is not required for import of subunit 6 of the cytochrome bc1 complex into yeast mitochondria or assembly into the complex. DeLabre ML, et al. FEBS Lett, 1999 Apr 23. PMID 10338132
    4. Identification of novel homologues of three low molecular weight subunits of the mitochondrial bc1 complex. Braun HP. Mol Biol Rep, 1996. PMID 8983020
    5. Deletion of QCR6, the gene encoding subunit six of the mitochondrial cytochrome bc1 complex, blocks maturation of cytochrome c1, and causes temperature-sensitive petite growth in Saccharomyces cerevisiae. Yang M, et al. J Biol Chem, 1994 Jan 14. PMID 8288589

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquinol-cytochrome-c reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase subunit 6
    NP_116691.3
    • Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      224326..224769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179998.3 → NP_116691.3  TPA: ubiquinol--cytochrome-c reductase subunit 6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116691.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTR6, P00127
      UniProtKB/TrEMBL
      A7A273, B3LUP4, C8Z7X0, G2WDH4, N1P520
      Conserved Domains (1) summary
      pfam02320
      Location:76 → 147
      UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00127.2

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