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    RPM2 ribonuclease P [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854883, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RPM2
    Official Full Name
    ribonuclease P
    Primary source
    SGD:S000004556
    Locus tag
    YML091C
    See related
    AllianceGenome:SGD:S000004556; FungiDB:YML091C; VEuPathDB:YML091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ribonuclease P activity. Involved in gene expression; mitochondrion organization; and positive regulation of transcription by RNA polymerase II. Located in mitochondrial matrix and nucleus. Part of mitochondrial ribonuclease P complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPM2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (87123..90731, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Utp14p Neighboring gene proteasome core particle subunit alpha 2 Neighboring gene ncRNA Neighboring gene SCF ubiquitin ligase complex subunit UFO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A 105-kDa protein is required for yeast mitochondrial RNase P activity. Morales MJ, et al. Proc Natl Acad Sci U S A, 1992 Oct 15. PMID 1409716, Free PMC Article
    2. Yeast mitochondrial RNase P RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNA-processing enzyme. Stribinskis V, et al. Mol Cell Biol, 1996 Jul. PMID 8668158, Free PMC Article
    3. Mitochondrial RNase P: the RNA family grows. Martin NC, et al. Nucleic Acids Symp Ser, 1997. PMID 9478201
    4. RNase P activity in the mitochondria of Saccharomyces cerevisiae depends on both mitochondrion and nucleus-encoded components. Hollingsworth MJ, et al. Mol Cell Biol, 1986 Apr. PMID 3537697, Free PMC Article
    5. RPM2, independently of its mitochondrial RNase P function, suppresses an ISP42 mutant defective in mitochondrial import and is essential for normal growth. Kassenbrock CK, et al. Mol Cell Biol, 1995 Sep. PMID 7544434, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpm2p has a transcriptional activation domain and plays a role in defining the mRNAs for some nucleus-encoded mitochondrial components.
      Title: Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus.
    2. Rpm2p appears to function as a coordinator of transcription and mRNA storage/decay in P bodies.
      Title: Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitochondrial tRNA 5'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease P
    NP_013619.1
    • Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      87123..90731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182450.1 → NP_013619.1  TPA: ribonuclease P [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J4, Q02773
      UniProtKB/TrEMBL
      G2WJW6
      Conserved Domains (2) summary
      sd00004
      Location:194 → 216
      PPR; PPR repeat [structural motif]
      pfam08579
      Location:163 → 281
      RPM2; Mitochondrial ribonuclease P subunit (RPM2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02773.1

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