U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rcsA DNA-binding transcriptional activator RcsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946467, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rcsA
    Official Full Name
    DNA-binding transcriptional activator RcsA
    Primary source
    ECOCYC:EG10820
    Locus tag
    b1951
    See related
    ASAP:ABE-0006482
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cpsR; ECK1949
    Summary
    The binding site length comes from a single reference . [More information is available at EcoCyc: EG10820].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2023968..2024591)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar biosynthesis protein FliQ Neighboring gene flagellar biosynthesis protein FliR Neighboring gene protein DsrB Neighboring gene stress-induced protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role of RcsA in the adaptation and survival of Escherichia coli K92. Navasa N, et al. FEMS Microbiol Lett, 2019 Apr 1. PMID 31089698
    2. Expression of Vi antigen in Escherichia coli K-12: characterization of ViaB from Citrobacter freundii and identity of ViaA with RcsB. Houng HS, et al. J Bacteriol, 1992 Sep. PMID 1522067, Free PMC Article
    3. Acyl-homoserine lactones can induce virus production in lysogenic bacteria: an alternative paradigm for prophage induction. Ghosh D, et al. Appl Environ Microbiol, 2009 Nov. PMID 19783745, Free PMC Article
    4. RcsA, an unstable positive regulator of capsular polysaccharide synthesis. Stout V, et al. J Bacteriol, 1991 Mar. PMID 1999391, Free PMC Article
    5. Regulation of capsule synthesis includes interactions of the RcsC/RcsB regulatory pair. Stout V. Res Microbiol, 1994 Jun-Aug. PMID 7855424

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results show that RcsA protects E. coli K92 against osmotic and, especially, oxidative stress at low temperatures.
      Title: The role of RcsA in the adaptation and survival of Escherichia coli K92.
    2. The authors conclude that RcsA is indeed proteolized by ClpYQ protease.
      Title: The degradation of RcsA by ClpYQ(HslUV) protease in Escherichia coli.
    3. These mutant rpoB RNA polymerases affect rcsA transcription, but per se are not defective either at rcsA or at cps promoters ande hence lead to increased capsular polysaccharide synthesis in Deltalon strains of Escherichia coli.
      Title: Suppression of capsule expression in Δlon strains of Escherichia coli by two novel rpoB mutations in concert with HNS: possible role for DNA bending at rcsA promoter.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: RcsA, an unstable positive regulator of capsular polysaccharide synthesis.
    5. We showed that the poor growth at 37 degrees C was corrected by disruption of the rcsA gene, which codes for a coregulator protein that interacts with the RcsB response regulator of the phosphorelay system.
      Title: RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bacterial-type flagellum-dependent cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of capsule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional activator RcsA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2023968..2024591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416461.1 DNA-binding transcriptional activator RcsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416461.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9JHE8
      Conserved Domains (1) summary
      PRK15411
      Location:1 → 207
      rcsA; transcriptional regulator RcsA
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.