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    emrK tripartite efflux pump membrane fusion protein EmrK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946840, updated on 3-Dec-2024

    Summary

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    Official Symbol
    emrK
    Official Full Name
    tripartite efflux pump membrane fusion protein EmrK
    Primary source
    ECOCYC:G7233
    Locus tag
    b2368
    See related
    ASAP:ABE-0007808
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2364
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG13282]. EmrK and EmrY show sequence similarity to EmrA and EmrB respectively. [More information is available at EcoCyc: G7233].
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    Genomic context

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    Sequence:
    NC_000913.3 (2482176..2483339, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-serine ammonia-lyase Neighboring gene tripartite efflux pump membrane subunit EmrY Neighboring gene protein EvgL Neighboring gene DNA-binding transcriptional activator EvgA Neighboring gene sensor histidine kinase EvgS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. May T, et al. Antimicrob Agents Chemother, 2009 Nov. PMID 19721076, Free PMC Article
    2. Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12. Kato A, et al. Biosci Biotechnol Biochem, 2000 Jun. PMID 10923791
    3. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. Nishino K, et al. J Bacteriol, 2001 Feb. PMID 11157960, Free PMC Article
    4. Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline. Tanabe H, et al. J Gen Appl Microbiol, 1997 Oct. PMID 12501312
    5. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. Nishino K, et al. J Bacteriol, 2004 Mar. PMID 14973023, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite efflux pump membrane fusion protein EmrK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2482176..2483339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416869.1 tripartite efflux pump membrane fusion protein EmrK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416869.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2G0N8
      Conserved Domains (1) summary
      TIGR00998
      Location:14 → 338
      8a0101; efflux pump membrane protein (multidrug resistance protein A)
    Nucleotide Protein
    Heading Accession and Version

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