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    proX glycine betaine ABC transporter periplasmic binding protein ProX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947165, updated on 17-Dec-2024

    Summary

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    Official Symbol
    proX
    Official Full Name
    glycine betaine ABC transporter periplasmic binding protein ProX
    Primary source
    ECOCYC:EG10773
    Locus tag
    b2679
    See related
    ASAP:ABE-0008818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2673; osrA; proU
    Summary
    The cold-inducibility of proX is dependent on the presence of the pnp gene. [More information is available at EcoGene: EG10773]. ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10773].
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    Genomic context

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    Sequence:
    NC_000913.3 (2807132..2808124)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW Neighboring gene pseudo Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli. Schiefner A, et al. J Biol Chem, 2004 Feb 13. PMID 14612446
    2. Functional reconstitution and osmoregulatory properties of the ProU ABC transporter from Escherichia coli. Gul N, et al. Mol Membr Biol, 2013 Mar. PMID 23249124
    3. Osmotic control of proU transcription is mediated through direct action of potassium glutamate on the transcription complex. Prince WS, et al. J Biol Chem, 1990 Oct 15. PMID 1976630
    4. Osmoregulation in Escherichia coli: complementation analysis and gene-protein relationships in the proU locus. Dattananda CS, et al. J Bacteriol, 1989 Apr. PMID 2649478, Free PMC Article
    5. Cloned structural genes for the osmotically regulated binding-protein-dependent glycine betaine transport system (ProU) of Escherichia coli K-12. Faatz E, et al. Mol Microbiol, 1988 Mar. PMID 2837616

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Purification and characterization of a glycine betaine binding protein from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables quaternary ammonium group binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycine betaine transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ProVWX complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine betaine ABC transporter periplasmic binding protein ProX
    NP_417165.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2807132..2808124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417165.1 glycine betaine ABC transporter periplasmic binding protein ProX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417165.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AT13
      Conserved Domains (1) summary
      PRK11119
      Location:1 → 330
      proX; proline/glycine betaine ABC transporter substrate-binding protein ProX
    Nucleotide Protein
    Heading Accession and Version

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