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    acrF multidrug efflux pump RND permease AcrF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947768, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acrF
    Official Full Name
    multidrug efflux pump RND permease AcrF
    Primary source
    ECOCYC:EG10267
    Locus tag
    b3266
    See related
    ASAP:ABE-0010724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3253; envD
    Summary
    AcrEF confers resistance to nalidixic acid, acriflavin, indole and solvents. [More information is available at EcoGene: EG10267]. AcrEF is a multidrug efflux system in Escherichia coli that is highly homologous to the AcrAB multidrug efflux system . [More information is available at EcoCyc: EG10267].
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    Genomic context

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    Sequence:
    NC_000913.3 (3415033..3418137)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor EnvR Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrE Neighboring gene lipoprotein YhdV Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locations of the envCD genes on the physical map of the Escherichia coli chromosome. Klein JR, et al. J Bacteriol, 1992 Jun. PMID 1592834, Free PMC Article
    2. Role of multiple efflux pumps in Escherichia coli in indole expulsion. Kawamura-Sato K, et al. FEMS Microbiol Lett, 1999 Oct 15. PMID 10518736
    3. Multidrug resistance pumps in bacteria: variations on a theme. Lewis K. Trends Biochem Sci, 1994 Mar. PMID 8203018
    4. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. Lau SY, et al. J Bacteriol, 2005 Nov. PMID 16267305, Free PMC Article
    5. Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Bohnert JA, et al. Antimicrob Agents Chemother, 2005 Feb. PMID 15673787, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug efflux pump RND permease AcrF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3415033..3418137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417732.1 multidrug efflux pump RND permease AcrF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417732.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3IP00
      Conserved Domains (1) summary
      TIGR00915
      Location:1 → 1034
      2A0602; The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family
    Nucleotide Protein
    Heading Accession and Version

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