U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fruK 1-phosphofructokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946676, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fruK
    Official Full Name
    1-phosphofructokinase
    Primary source
    ECOCYC:EG10337
    Locus tag
    b2168
    See related
    ASAP:ABE-0007174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2161; fpk
    Summary
    Repressed during biofilm formation. [More information is available at EcoGene: EG10337]. 1-phosphofructokinase is essential for the utilization of fructose as a carbon source. [More information is available at EcoCyc: EG10337].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2261427..2262365, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudouridine-5'-phosphate glycosidase Neighboring gene putative pseudouridine kinase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruA Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruB Neighboring gene sugar exporter SetB Neighboring gene putative metal-chelating domain-containing protein YeiW

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fructose-1-kinase has pleiotropic roles in Escherichia coli. Weeramange C, et al. J Biol Chem, 2024 Jun. PMID 38723750, Free PMC Article
    2. The utilization of fructose by Escherichia coli. Properties of a mutant defective in fructose 1-phosphate kinase activity. Ferenci T, et al. Biochem J, 1973 Feb. PMID 4579702, Free PMC Article
    3. Overexpression and purification of fructose-1-phosphate kinase from Escherichia coli: application to the assay of fructose 1-phosphate. Veiga-da-Cunha M, et al. Protein Expr Purif, 2000 Jun. PMID 10833389
    4. Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus. Orchard LM, et al. Proc Biol Sci, 1990 Nov 22. PMID 1981619
    5. Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens. Dodgson C, et al. J Bacteriol, 1996 Apr. PMID 8606162, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fructose-1-kinase has pleiotropic roles in Escherichia coli.
      Title: Fructose-1-kinase has pleiotropic roles in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphofructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphofructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fructose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    1-phosphofructokinase
    NP_416673.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2261427..2262365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416673.1 1-phosphofructokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416673.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AH55
      Conserved Domains (1) summary
      PRK09513
      Location:1 → 312
      fruK; 1-phosphofructokinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.