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    hsdM type I restriction enzyme EcoKI methylase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948872, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hsdM
    Official Full Name
    type I restriction enzyme EcoKI methylase subunit
    Primary source
    ECOCYC:EG10458
    Locus tag
    b4349
    See related
    ASAP:ABE-0014260
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4339; hsm; hsp
    Summary
    HsdM is the modification methyltransferase component of the EcoKI restriction-modification system . [More information is available at EcoCyc: EG10458].
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    Genomic context

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    Sequence:
    NC_000913.3 (4581459..4583048, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type IV methyl-directed restriction enzyme EcoKMcrBC subunit Neighboring gene 5-methylcytosine-specific restriction enzyme subunit McrB;McrBS Neighboring gene nucleoid-associated protein SymE Neighboring gene ncRNA Neighboring gene type I restriction enzyme EcoKI specificity subunit Neighboring gene type I restriction enzyme EcoKI endonuclease subunit Neighboring gene Type IV methyl-directed restriction enzyme EcoKMrr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Method for isolating restriction- and modificationless mutants of Escherichia coli K-12. Del Giudice L. J Bacteriol, 1979 Jan. PMID 368038, Free PMC Article
    2. Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle). Murray NE. Microbiol Mol Biol Rev, 2000 Jun. PMID 10839821, Free PMC Article
    3. The hsd (host specificity) genes of E. coli K 12. Sain B, et al. Mol Gen Genet, 1980. PMID 6255295
    4. Restriction and modification of DNA by a complex protein. Yuan R, et al. Am Sci, 1982 Jan-Feb. PMID 6282152
    5. Substrate recognition and selectivity in the type IC DNA modification methylase M.EcoR124I. Taylor I, et al. Nucleic Acids Res, 1993 Oct 25. PMID 8177741, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables site-specific DNA-methyltransferase (adenine-specific) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA restriction-modification system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA restriction-modification system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of type I site-specific deoxyribonuclease complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type I restriction enzyme EcoKI methylase subunit
    NP_418769.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4581459..4583048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418769.1 type I restriction enzyme EcoKI methylase subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418769.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PEX5
      Conserved Domains (2) summary
      pfam02384
      Location:122 → 450
      N6_Mtase; N-6 DNA Methylase
      pfam12161
      Location:6 → 101
      HsdM_N; HsdM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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