U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gpt xanthine-guanine phsophoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944817, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gpt
    Official Full Name
    xanthine-guanine phsophoribosyltransferase
    Primary source
    ECOCYC:EG10414
    Locus tag
    b0238
    See related
    ASAP:ABE-0000814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0239; glyD; gpp; gxu
    Summary
    Xanthine-guanine phosphoribosyltransferase is a purine salvage enzyme which converts either xanthine or guanine to XMP or GMP, respectively. [More information is available at EcoCyc: EG10414].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (255977..256435)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene peptidase D Neighboring gene fermentation-respiration switch protein Neighboring gene IS1 family transposase B Neighboring gene pseudo Neighboring gene IS1 family repressor TnpA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Purification and characterization of Escherichia coli guanine-xanthine phosphoribosyltransferase produced by a high efficiency expression plasmid utilizing a lambda PL promoter and CI857 temperature-sensitive repressor. Liu SW, et al. J Biol Chem, 1983 Jun 25. PMID 6305942
    2. Nucleotide sequence and analysis of deletion mutants of the Escherichia coli gpt gene in plasmid pSV2 gpt. Jagadeeswaran P, et al. Gene, 1984 Nov. PMID 6396164
    3. Nucleotide sequence of the Escherichia coli xanthine-guanine phosphoribosyl transferase gene. Pratt D, et al. Nucleic Acids Res, 1983 Dec 20. PMID 6324103, Free PMC Article
    4. Mechanism of adenine toxicity in Escherichia coli. Levine RA, et al. J Bacteriol, 1982 Mar. PMID 6801015, Free PMC Article
    5. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Mulligan RC, et al. Proc Natl Acad Sci U S A, 1981 Apr. PMID 7017722, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.
      Title: Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.
    2. Data suggest that arsenite induces guanine phosphoribosyltransferase gpt G:C to T:A transversions through oxidative-stress-induced 8-OHdG formation.
      Title: In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables xanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within IMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in XMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in XMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within XMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    xanthine-guanine phsophoribosyltransferase
    NP_414773.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      255977..256435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414773.1 xanthine-guanine phsophoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414773.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7K443
      Conserved Domains (1) summary
      PRK09177
      Location:1 → 152
      PRK09177; xanthine-guanine phosphoribosyltransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.