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    nrdD anaerobic ribonucleoside-triphosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948755, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nrdD
    Official Full Name
    anaerobic ribonucleoside-triphosphate reductase
    Primary source
    ECOCYC:EG11417
    Locus tag
    b4238
    See related
    ASAP:ABE-0013865
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4233
    Summary
    Activated NrdD is predicted to be cleaved by oxygen at the Gly681 radical, dropping the last 31 aa. [More information is available at EcoGene: EG11417]. The NrdD reductase is activated by the NrdG activase under anaerobic conditions and is inactivated by oxygen. [More information is available at EcoCyc: EG11417].
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    Genomic context

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    Sequence:
    NC_000913.3 (4460522..4462660, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase activating protein Neighboring gene trehalose-6-phosphate hydrolase Neighboring gene trehalose-specific PTS enzyme IIBC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of components of the anaerobic ribonucleotide reductase system from Escherichia coli. Eliasson R, et al. J Biol Chem, 1992 Dec 15. PMID 1460049
    2. The Zn center of the anaerobic ribonucleotide reductase from E. coli. Luttringer F, et al. J Biol Inorg Chem, 2009 Aug. PMID 19381696
    3. Activation of the anaerobic ribonucleotide reductase from Escherichia coli by S-adenosylmethionine. Harder J, et al. J Biol Chem, 1992 Dec 15. PMID 1460050
    4. Oxygen-sensitive ribonucleoside triphosphate reductase is present in anaerobic Escherichia coli. Fontecave M, et al. Proc Natl Acad Sci U S A, 1989 Apr. PMID 2648390, Free PMC Article
    5. Characterization of an iron sensitive Mud1 mutant in E. coli lacking the ribonucleotide reductase subunit B2. Hantke K. Arch Microbiol, 1988. PMID 2833197

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dGTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyrimidine deoxyribonucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribonucleoside-triphosphate reductase (thioredoxin) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside-triphosphate reductase (thioredoxin) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside-triphosphate reductase (thioredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 2'-deoxyribonucleotide biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in 2'-deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 2'-deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 2'-deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 2'-deoxyribonucleotide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing small molecule interconversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing small molecule interconversion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaerobic ribonucleoside-triphosphate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaerobic ribonucleoside-triphosphate reductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaerobic ribonucleoside-triphosphate reductase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaerobic ribonucleoside-triphosphate reductase
    NP_418659.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4460522..4462660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418659.1 anaerobic ribonucleoside-triphosphate reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418659.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0NDP9, A0A5B9AQK8
      Conserved Domains (1) summary
      PRK09263
      Location:1 → 711
      PRK09263; anaerobic ribonucleoside triphosphate reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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