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    dkgB methylglyoxal reductase DkgB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944901, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dkgB
    Official Full Name
    methylglyoxal reductase DkgB
    Primary source
    ECOCYC:EG11648
    Locus tag
    b0207
    See related
    ASAP:ABE-0000692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0207; yafB
    Summary
    DkgB is a member of a new aldo-keto reductase (AKR) subfamily 3F . [More information is available at EcoCyc: EG11648].
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    Genomic context

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    Sequence:
    NC_000913.3 (229167..229970)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene tRNA-Asp Neighboring gene DNA-binding transcriptional regulator YafC Neighboring gene endonuclease/exonuclease/phosphatase domain-containing protein YafD Neighboring gene putative S-adenosylmethionine-dependent methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the yqhE and yafB genes encoding two 2, 5-diketo-D-gluconate reductases in Escherichia coli. Yum DY, et al. Appl Environ Microbiol, 1999 Aug. PMID 10427017, Free PMC Article
    2. Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Di Luccio E, et al. Biochem J, 2006 Nov 15. PMID 16813561, Free PMC Article
    3. Sequence of the distal tRNA1Asp gene and the transcription termination signal in the Escherichia coli ribosomal RNA operon rrnF(or G). Sekiya T, et al. Nucleic Acids Res, 1980 Sep 11. PMID 6255418, Free PMC Article
    4. Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases. Ko J, et al. J Bacteriol, 2005 Aug. PMID 16077126, Free PMC Article
    5. A new model for the anaerobic fermentation of glycerol in enteric bacteria: trunk and auxiliary pathways in Escherichia coli. Gonzalez R, et al. Metab Eng, 2008 Sep. PMID 18632294

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl-alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylglyoxal catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylglyoxal reductase DkgB
    NP_414743.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      229167..229970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414743.1 methylglyoxal reductase DkgB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414743.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YBZ2
      Conserved Domains (1) summary
      PRK11172
      Location:1 → 267
      dkgB; 2,5-didehydrogluconate reductase DkgB
    Nucleotide Protein
    Heading Accession and Version

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