gcl glyoxylate carboligase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: gcl
Official Full Name: glyoxylate carboligase
Primary source: ECOCYC:EG11583
Locus tag: b0507
See related: ASAP:ABE-0001754
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0500
Summary: Glyoxylate carboligase condenses two molecules of glyoxylate to form tartronate semialdehyde. [More information is available at EcoCyc: EG11583].
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NC_000913.3 Genomic Context describing neighboring genes

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Glyoxylate carboligase thus provides a unique illustration of the fine tuning between catalytic stages imposed during evolution on enzymes catalyzing multistep processes
Title: Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes.
N-terminus verified by Edman degradation on mature peptide
Title: Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables tartronate-semialdehyde synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tartronate-semialdehyde synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables tartronate-semialdehyde synthase activity	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyoxylate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glyoxylate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info

NP_415040.1

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