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    kefF regulator of KefC-mediated potassium transport and quinone oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944767, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kefF
    Official Full Name
    regulator of KefC-mediated potassium transport and quinone oxidoreductase
    Primary source
    ECOCYC:EG11568
    Locus tag
    b0046
    See related
    ASAP:ABE-0000159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0047; yabF
    Summary
    Based on sequence similarity, YabF is predicted to be an NAD(P)H dehydrogenase . [More information is available at EcoCyc: EG11568].
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    Genomic context

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    Sequence:
    NC_000913.3 (47246..47776)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase FixC Neighboring gene putative ferredoxin FixX Neighboring gene putative transporter YaaU Neighboring gene K(+) : H(+) antiporter KefC Neighboring gene dihydrofolate reductase Neighboring gene diadenosine tetraphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity. Lyngberg L, et al. J Bacteriol, 2011 Sep. PMID 21742892, Free PMC Article
    2. Construction and screening of metagenomic libraries derived from enrichment cultures: generation of a gene bank for genes conferring alcohol oxidoreductase activity on Escherichia coli. Knietsch A, et al. Appl Environ Microbiol, 2003 Mar. PMID 12620823, Free PMC Article
    3. KTN (RCK) domains regulate K+ channels and transporters by controlling the dimer-hinge conformation. Roosild TP, et al. Structure, 2009 Jun 10. PMID 19523906, Free PMC Article
    4. Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation. Miller S, et al. J Biol Chem, 1997 Oct 3. PMID 9312097
    5. The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli. Munro AW, et al. Mol Microbiol, 1991 Mar. PMID 2046548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)H dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular pH elevation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of potassium:proton antiporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of KefC-mediated potassium transport and quinone oxidoreductase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      47246..47776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414588.1 regulator of KefC-mediated potassium transport and quinone oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414588.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6VS29
      Conserved Domains (1) summary
      PRK00871
      Location:1 → 176
      PRK00871; glutathione-regulated potassium-efflux system oxidoreductase KefF
    Nucleotide Protein
    Heading Accession and Version

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