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    mazE antitoxin of the MazF-MazE toxin-antitoxin system MazE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947245, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mazE
    Official Full Name
    antitoxin of the MazF-MazE toxin-antitoxin system MazE
    Primary source
    ECOCYC:EG10571
    Locus tag
    b2783
    See related
    ASAP:ABE-0009122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chpAI; chpR; ECK2777
    Summary
    MazE and the MazE-MazF complex bind DNA in the mazEF promoter region. [More information is available at EcoGene: EG10571]. MazE is an antitoxin that counteracts MazF toxin . [More information is available at EcoCyc: EG10571].
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    Genomic context

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    Sequence:
    NC_000913.3 (2911091..2911339, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene CTP synthetase Neighboring gene nucleoside triphosphate pyrophosphohydrolase Neighboring gene endoribonuclease toxin MazF Neighboring gene GDP/GTP pyrophosphokinase Neighboring gene 23S rRNA m(5)U1939 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Kamphuis MB, et al. Proteins, 2007 Apr 1. PMID 17206710
    2. Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins? Lah J, et al. J Biol Chem, 2005 Apr 29. PMID 15735309
    3. Crystal structure of the intrinsically flexible addiction antidote MazE. Loris R, et al. J Biol Chem, 2003 Jul 25. PMID 12743116
    4. Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF. Li GY, et al. J Mol Biol, 2006 Mar 17. PMID 16413577
    5. Bacterial programmed cell death and multicellular behavior in bacteria. Engelberg-Kulka H, et al. PLoS Genet, 2006 Oct. PMID 17069462, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The increase in growth rate heterogeneity is governed by the MazE antitoxin, and tuned by the MazF-dependent mazF mRNA cleavage.
      Title: Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations.
    2. study could not reproduce mazEF mediated programmed cell death
      Title: Escherichia coli MazEF toxin-antitoxin system does not mediate programmed cell death.
    3. The MazE C-terminus plays an important role in the MazF binding, which was found to increase the MazE affinity for the palindromic single site operator.
      Title: Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.
    4. The mazE and mazF-mediated cell death pathway prevents the effect of DNA damage on membrane depolarization in E. coli.
      Title: Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway.
    5. Deletion of rpoS, the gene encoding sigma(S) from the bacterial chromosome, permitted mazEF-mediated cell death during stationary growth phase.
      Title: The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death.
    6. our results showed that the mode of action of antibiotics was determined by the ability of E. coli cells to communicate through the signaling molecule Extracellular Death Factor (EDF) participating in mazEF induction.
      Title: The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics.
    7. study reports that E. coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF); structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn
      Title: A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli.
    8. effect of mazEF on the development of bacteriophage P1
      Title: Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1.
    9. analysis of energetics of structural transitions of the addiction antitoxin MazE
      Title: Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins?
    10. results reported here support the view that the mazEF module mediates cell death and is part of a programmed cell death network
      Title: MazF-mediated cell death in Escherichia coli: a point of no return.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxin sequestering activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables toxin sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxin sequestering activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin of the MazF-MazE toxin-antitoxin system MazE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2911091..2911339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417263.1 antitoxin of the MazF-MazE toxin-antitoxin system MazE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417263.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377CV50
      Conserved Domains (1) summary
      PRK09798
      Location:1 → 82
      PRK09798; MazF-MazE toxin-antitoxin system antitoxin MazE
    Nucleotide Protein
    Heading Accession and Version

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