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    argO L-arginine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947418, updated on 3-Dec-2024

    Summary

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    Official Symbol
    argO
    Official Full Name
    L-arginine exporter
    Primary source
    ECOCYC:EG11159
    Locus tag
    b2923
    See related
    ASAP:ABE-0009591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2919; yggA
    Summary
    LysE family. [More information is available at EcoGene: EG11159]. The ArgO (YggA) protein is a member of the LysE family of lysine efflux transporters . [More information is available at EcoCyc: EG11159].
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    Genomic context

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    Sequence:
    NC_000913.3 (3068173..3068808, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI Neighboring gene DUF541 domain-containing protein YggE Neighboring gene small conductance mechanosensitive channel MscS Neighboring gene fructose-bisphosphate aldolase class II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function. Pathania A, et al. J Bacteriol, 2016 Dec 1. PMID 27645388, Free PMC Article
    2. Environmental regulation operating at the promoter clearance step of bacterial transcription. Laishram RS, et al. Genes Dev, 2007 May 15. PMID 17504942, Free PMC Article
    3. Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP. Peeters E, et al. Mol Microbiol, 2009 Dec. PMID 19906180
    4. Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli. Alefounder PR, et al. Mol Microbiol, 1989 Jun. PMID 2546007
    5. Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli. Nandineni MR, et al. J Bacteriol, 2004 Jun. PMID 15150242, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A pair of conserved aspartate residues, located near the opposing edges of ArgO plays a pivotal role in facilitating transmembrane Arg flux.
      Title: The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function.
    2. Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
      Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-arginine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-arginine transmembrane transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within L-arginine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-arginine exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3068173..3068808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417398.1 L-arginine exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417398.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W8T9S8
      Conserved Domains (1) summary
      PRK09304
      Location:1 → 207
      PRK09304; arginine exporter ArgO
    Nucleotide Protein
    Heading Accession and Version

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