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    nudC RNA decapping hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948498, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nudC
    Official Full Name
    RNA decapping hydrolase
    Primary source
    ECOCYC:EG11702
    Locus tag
    b3996
    See related
    ASAP:ABE-0013063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3988; yjaD
    Summary
    Nudix hydrolase. [More information is available at EcoGene: EG11702]. NudC belongs to the family of "Nudix" hydrolases . [More information is available at EcoCyc: EG11702].
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    Genomic context

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    Sequence:
    NC_000913.3 (4196903..4197676)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene thiamine phosphate synthase Neighboring gene phosphomethylpyrimidine synthase Neighboring gene regulator of sigma D Neighboring gene uroporphyrinogen decarboxylase Neighboring gene endonuclease V

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of prokaryotic NAD-RNA decapping by NudC. Zhang D, et al. Cell Res, 2016 Sep. PMID 27561816, Free PMC Article
    2. Structure and function of the bacterial decapping enzyme NudC. Höfer K, et al. Nat Chem Biol, 2016 Sep. PMID 27428510, Free PMC Article
    3. NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs. Cahová H, et al. Nature, 2015 Mar 19. PMID 25533955
    4. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
    5. Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium. Monsieurs P, et al. J Mol Evol, 2005 Apr. PMID 15883881

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. xray crystallography of NudC
      Title: Structural basis of prokaryotic NAD-RNA decapping by NudC.
    2. The Escherichia coli NudC strongly prefers NAD-linked RNA (NAD-RNA) over NAD and binds to a diverse set of cellular RNAs in an unspecific manner.
      Title: Structure and function of the bacterial decapping enzyme NudC.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA NAD-cap (NMN-forming) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA NAD-cap (NMN-forming) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA decapping hydrolase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4196903..4197676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026280.1 RNA decapping hydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026280.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FUK0
      Conserved Domains (1) summary
      PRK00241
      Location:1 → 252
      nudC; NAD(+) diphosphatase
    Nucleotide Protein
    Heading Accession and Version

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