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    MAK21 RNA-binding ribosome biosynthesis protein MAK21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAK21
    Official Full Name
    RNA-binding ribosome biosynthesis protein MAK21
    Primary source
    SGD:S000002467
    Locus tag
    YDR060W
    See related
    AllianceGenome:SGD:S000002467; FungiDB:YDR060W; VEuPathDB:YDR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NOC1
    Summary
    Enables mRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Part of Noc1p-Noc2p complex. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAK21 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (570649..573726)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene E2 ubiquitin-conjugating protein UBC5 Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The origin of nucleus: rebuild from the prokaryotic ancestors of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Nov 1. PMID 18620034
    2. Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. Edskes HK, et al. J Biol Chem, 1998 Oct 30. PMID 9786894
    3. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
    4. The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome. Kühn H, et al. PLoS One, 2009 Dec 18. PMID 20019888, Free PMC Article
    5. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding ribosome biosynthesis protein MAK21
    NP_010345.3
    • Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      570649..573726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180368.3 → NP_010345.3  TPA: RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010345.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS46, Q12176
      UniProtKB/TrEMBL
      A6ZY25, C7GVS6, C8Z4X9
      Conserved Domains (1) summary
      COG5593
      Location:173 → 1022
      COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12176.1

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