PHO87 SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHO87
Official Full Name: SPX domain-containing inorganic phosphate transporter
Primary source: SGD:S000000633
Locus tag: YCR037C
See related: AllianceGenome:SGD:S000000633; FungiDB:YCR037C; VEuPathDB:YCR037C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphate transmembrane transporter activity. Involved in several processes, including plasma membrane selenite transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PHO87 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (194414..197185, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pho87 and Pho90 represent non-redundant P(i) transporters, which are tuned by the integration of multiple nutrient signalling mechanisms in order to adjust P(i)-transport capacity to the general nutritional status of the environment.
Title: Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
However, our results revealed that Ddi1p and its associated protein Rad23p are not involved in the decrease in Pho81p level under high-phosphate condition.
Title: Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cyp27b1 (e-PCR), detects polymorphism
- UniSTS:546718

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in plasma membrane selenite transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SPX domain-containing inorganic phosphate transporter

NP_009966.2

Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of PHO pathway; targeted to vacuole via AP-3 pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

194414..197185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178751.1 → NP_009966.2 TPA: SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009966.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR47, P25360

UniProtKB/TrEMBL

B3LUA6, C8Z4C7, N1PAQ5

Conserved Domains (2) summary

COG5408
Location:1 → 334

COG5408; SPX domain-containing protein [Signal transduction mechanisms]

cd01115
Location:487 → 914

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...