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    MSS2 Mss2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSS2
    Official Full Name
    Mss2p
    Primary source
    SGD:S000002265
    Locus tag
    YDL107W
    See related
    AllianceGenome:SGD:S000002265; FungiDB:YDL107W; VEuPathDB:YDL107W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSS2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (268921..269976)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative lipase Neighboring gene TFIIH complex serine/threonine-protein kinase subunit KIN28 Neighboring gene Pho2p Neighboring gene Smc5-Smc6 complex subunit NSE4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nuclear-encoded MSS2 gene is involved in the expression of the mitochondrial cytochrome-c oxidase subunit 2 (Cox2). Simon M, et al. Biochim Biophys Acta, 1995 Feb 14. PMID 7857963
    2. Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Saracco SA, et al. Mol Biol Cell, 2002 Apr. PMID 11950926, Free PMC Article
    3. The sequence of a 20.3 kb DNA fragment from the left arm of Saccharomyces cerevisiae chromosome IV contains the KIN28, MSS2, PHO2, POL3 and DUN1 genes, and six new open reading frames. Saiz JE, et al. Yeast, 1996 Sep. PMID 8896274
    4. Peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C tail in Saccharomyces cerevisiae. Broadley SA, et al. Mol Cell Biol, 2001 Nov. PMID 11604502, Free PMC Article
    5. Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Fiumera HL, et al. Mol Cell Biol, 2007 Jul. PMID 17452441, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane from matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mss2p
    NP_010176.1
    • Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      268921..269976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180166.1 → NP_010176.1  TPA: Mss2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP3, P40990
      UniProtKB/TrEMBL
      G2WC55, N1PA92
      Conserved Domains (1) summary
      TIGR02917
      Location:136 → 240
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40990.2

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