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    TRP2 anthranilate synthase TRP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856824, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRP2
    Official Full Name
    anthranilate synthase TRP2
    Primary source
    SGD:S000000892
    Locus tag
    YER090W
    See related
    AllianceGenome:SGD:S000000892; FungiDB:YER090W; VEuPathDB:YER090W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables anthranilate synthase activity. Involved in tryptophan biosynthetic process. Located in cytoplasm. Part of anthranilate synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TRP2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (337949..339472)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Dot6p Neighboring gene type 2C protein phosphatase PTC2 Neighboring gene 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase Neighboring gene Ies5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. Graf R, et al. J Bacteriol, 1993 Feb. PMID 8432699, Free PMC Article
    2. Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae. Kornfeld O, et al. FEMS Microbiol Lett, 2005 Oct 1. PMID 16112818
    3. Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae. Fantes PA, et al. Arch Microbiol, 1976 Mar 19. PMID 769720
    4. Stable substructures of eightfold beta alpha-barrel proteins: fragment complementation of phosphoribosylanthranilate isomerase. Eder J, et al. Biochemistry, 1992 Apr 14. PMID 1567820
    5. Purification and characterization of the indole-3-glycerolphosphate synthase/anthranilate synthase complex of Saccharomyces cerevisiae. Prantl F, et al. Eur J Biochem, 1985 Jan 2. PMID 3881257

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables anthranilate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables anthranilate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anthranilate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anthranilate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    anthranilate synthase TRP2
    NP_011014.1
    • Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      337949..339472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178981.1 → NP_011014.1  TPA: anthranilate synthase TRP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ7, P00899
      UniProtKB/TrEMBL
      B3LRK8, B5VHL7, C7GRS3, C8Z7A6, G2WCY1
      Conserved Domains (1) summary
      TIGR00564
      Location:37 → 494
      trpE_most; anthranilate synthase component I, non-proteobacterial lineages
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00899.4

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