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    HIS2 histidinol-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850581, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HIS2
    Official Full Name
    histidinol-phosphatase
    Primary source
    SGD:S000001921
    Locus tag
    YFR025C
    See related
    AllianceGenome:SGD:S000001921; FungiDB:YFR025C; VEuPathDB:YFR025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histidinol-phosphatase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HIS2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (203743..204750, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Pes4p Neighboring gene Lsb3p Neighboring gene tRNA-Ala Neighboring gene Uli1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of a gene required for the expression of allele-specific missense suppression in Saccharomyces cerevisiae. Gorman JA, et al. Genetics, 1971 Mar. PMID 4329443, Free PMC Article
    2. The separation and partial characterization of L-histidinol phosphatase and an alkaline phosphatase of Saccharomyces cerevisiae. Gorman JA, et al. J Biol Chem, 1969 Mar 25. PMID 4304232
    3. GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. FINK GR. Science, 1964 Oct 23. PMID 14190241
    4. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce DA, et al. J Bacteriol, 1999 Aug. PMID 10438744, Free PMC Article
    5. αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. Ponce-Rojas JC, et al. FEBS J, 2017 Mar. PMID 28109174

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histidinol-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidinol-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidinol-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    histidinol-phosphatase
    NP_116681.1
    • Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      203743..204750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179990.1 → NP_116681.1  TPA: histidinol-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTQ5, P38635
      UniProtKB/TrEMBL
      B3LUN4, B5VI52, C8Z7W0
      Conserved Domains (1) summary
      TIGR01856
      Location:2 → 292
      hisJ_fam; histidinol phosphate phosphatase, HisJ family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38635.2

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