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    PTR3 Ptr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850587, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PTR3
    Official Full Name
    Ptr3p
    Primary source
    SGD:S000001925
    Locus tag
    YFR029W
    See related
    AllianceGenome:SGD:S000001925; FungiDB:YFR029W; VEuPathDB:YFR029W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RAA2; SSY3
    Summary
    Involved in response to amino acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PTR3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (210937..212973)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase CDC14 Neighboring gene tRNA-Tyr Neighboring gene sulfite reductase subunit alpha Neighboring gene condensin subunit SMC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport. Island MD, et al. Curr Genet, 1991 Dec. PMID 1782673
    2. PTR3, a novel gene mediating amino acid-inducible regulation of peptide transport in Saccharomyces cerevisiae. Barnes D, et al. Mol Microbiol, 1998 Jul. PMID 9701822
    3. Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae. Poulsen P, et al. Eukaryot Cell, 2005 Jun. PMID 15947203, Free PMC Article
    4. Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae. Hauser M, et al. Mol Membr Biol, 2001 Jan-Mar. PMID 11396605
    5. Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I. Omnus DJ, et al. Mol Biol Cell, 2013 May. PMID 23447701, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
      Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
    2. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
      Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
    3. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
      Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    4. casein kinase I and PP2A phosphatase play antagonistic roles in SPS sensing by regulating Ptr3 phosphorylation
      Title: Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to amino acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ptr3p
    NP_116685.1
    • Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      210937..212973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179994.1 → NP_116685.1  TPA: Ptr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTQ9, P43606
      UniProtKB/TrEMBL
      G2WDG7, N1P399
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43606.1

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