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    SQT1 Sqt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SQT1
    Official Full Name
    Sqt1p
    Primary source
    SGD:S000001451
    Locus tag
    YIR012W
    See related
    AllianceGenome:SGD:S000001451; FungiDB:YIR012W; VEuPathDB:YIR012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in ribosomal large subunit assembly. Located in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SQT1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (378486..379781)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene MIND complex subunit DSN1 Neighboring gene Sts1p Neighboring gene Gat4p Neighboring gene Vld1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1. Eisinger DP, et al. Mol Cell Biol, 1997 Sep. PMID 9271392, Free PMC Article
    2. Sqt1p is an eight-bladed WD40 protein. Frénois F, et al. Acta Crystallogr F Struct Biol Commun, 2016 Jan. PMID 26750486, Free PMC Article
    3. GRC5 and NMD3 function in translational control of gene expression and interact genetically. Karl T, et al. Curr Genet, 1999 Jan. PMID 9933353
    4. Mutational analysis of the ribosomal protein Rpl10 from yeast. Hofer A, et al. J Biol Chem, 2007 Nov 9. PMID 17761675
    5. Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. West M, et al. Mol Cell Biol, 2005 May. PMID 15831484, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sqt1p
    NP_012277.1
    • Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      378486..379781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179534.1 → NP_012277.1  TPA: Sqt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVU2, P35184
      UniProtKB/TrEMBL
      C7GJG0, G2WGF8, N1P2A9
      Conserved Domains (2) summary
      COG2319
      Location:51 → 392
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:68 → 107
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35184.2

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