HBS1 HBS1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HBS1provided by FlyBase
Official Full Name: HBS1provided by FlyBase
Primary source: FLYBASE:FBgn0042712
Locus tag: Dmel_CG1898
See related: AllianceGenome:FB:FBgn0042712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1898; Dmel\CG1898; hbs1; Hbs1
Summary: Predicted to enable GTPase activity. Involved in post-transcriptional gene silencing; sperm individualization; and spermatocyte division. Located in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm anlage; head mesoderm; posterior endoderm; and trunk mesoderm. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1862881..1865240, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1862881..1865240, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
Title: Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatocyte division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain