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    Ost48 Oligosaccharyltransferase 48kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31849, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ost48provided by FlyBase
    Official Full Name
    Oligosaccharyltransferase 48kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014868
    Locus tag
    Dmel_CG9022
    See related
    AllianceGenome:FB:FBgn0014868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.11; CG9022; clone 1.11; Dmel\CG9022; DmOST50; DrOST; OST; ost48; OST48; OST48/WBP1; Ots48
    Summary
    Predicted to be involved in protein N-linked glycosylation via asparagine. Located in endomembrane system. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gland; gut section; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ost48 in Genome Data Viewer
    Location:
    8C14-8C14; 1-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9156929..9158515, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9050962..9052548, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Brahma associated protein 111kD Neighboring gene Histone H3.3B Neighboring gene Dorsal interacting protein 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PCR-mediated cloning and sequencing of the DmOST50 gene, a WBP1/AvOST50/OST48 homologue, from Drosophila melanogaster. Stagljar I, et al. Gene, 1995 Jun 9. PMID 7607543
    2. Structure and expression of histone H3.3 genes in Drosophila melanogaster and Drosophila hydei. Akhmanova AS, et al. Genome, 1995 Jun. PMID 7557364
    3. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Page SL, et al. Genetics, 2000 Aug. PMID 10924472, Free PMC Article
    4. Transcription in the absence of histone H3.3. Hödl M, et al. Curr Biol, 2009 Jul 28. PMID 19523831
    5. The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in Drosophilia. Glasscock E, et al. Genetics, 2005 Aug. PMID 15937125, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oligosaccharyltransferase 48kD subunit
    Names
    CG9022-PA
    Ost48-PA
    oligosaccaryltransferase 48kDa subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9156929..9158515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078541.4 → NP_511096.2  oligosaccharyltransferase 48kD subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511096.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24319, Q24355, Q9W382
      Related
      FBpp0071279
      Conserved Domains (1) summary
      pfam03345
      Location:27 → 437
      DDOST_48kD; Oligosaccharyltransferase 48 kDa subunit beta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24319.2 Q24319

    Gene LinkOut

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