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    MED20 Mediator complex subunit 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43952, updated on 4-Jan-2025

    Summary

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    Official Symbol
    MED20provided by FlyBase
    Official Full Name
    Mediator complex subunit 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0013531
    Locus tag
    Dmel_CG18780
    See related
    AllianceGenome:FB:FBgn0013531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18267; CG18780; Dmel\CG18780; dTrap26; dTrfp; l(2)28DE; med20; Med20; p29; Srb2/TRFP; Tmr; Trfp; TrfP
    Summary
    Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in spermatocyte and testis. Orthologous to human MED20 (mediator complex subunit 20). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See MED20 in Genome Data Viewer
    Location:
    28E1-28E1; 2-30 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8071812..8072848, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8071812..8072848, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L36A Neighboring gene Multiple EGF like domains 8 Neighboring gene purity of essence Neighboring gene TBP-related factor Neighboring gene Macroglobulin complement-related Neighboring gene antisense RNA:CR45257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diadenosine 5",5"'P1,P4-tetraphosphatase in Drosophila embryos: developmental regulation and characterization. Vallejo CG, et al. Int J Biochem, 1989. PMID 2558922
    2. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Crowley TE, et al. Nature, 1993 Feb 11. PMID 8429912
    3. Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. Yager J, et al. Proc Natl Acad Sci U S A, 2001 Aug 28. PMID 11517334, Free PMC Article
    4. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
    5. Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity. Park J, et al. Elife, 2019 Jun 21. PMID 31223115, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 20
    Names
    CG18780-PA
    CG18780-PB
    MED20-PA
    MED20-PB
    Trf-proximal
    lethal(2)28DE
    mediator
    transcription mediator-related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8071812..8072848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079924.3 → NP_524663.2  mediator complex subunit 20, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91641, Q9VLT4
      Related
      FBpp0079166
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 215
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

    2. NM_001273294.1 → NP_001260223.1  mediator complex subunit 20, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCC3
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 215
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCC3 M9PCC3
    P91641.2 P91641

    Gene LinkOut

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