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    ox oxen [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45401, updated on 17-Dec-2024

    Summary

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    Official Symbol
    oxprovided by FlyBase
    Official Full Name
    oxenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011227
    Locus tag
    Dmel_CG8764
    See related
    AllianceGenome:FB:FBgn0011227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH44662; CG8764; Dmel\CG8764; ms(2)00815; Qcr10; Qcr9; QCR9; UCRX; UQCR-7.2
    Summary
    Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including adult head; adult heart; amnioserosa; gut section; and spermatozoon. Orthologous to human UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    49C2-49C2; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12757133..12757529, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8644638..8645034, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mos oncogene Neighboring gene Diacyl glycerol kinase epsilon Neighboring gene Tafazzin Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene Nascent polypeptide associated complex protein alpha subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKepsilon. Frolov MV, et al. Biochim Biophys Acta, 2001 Apr 23. PMID 11336805
    2. The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activity. Frolov MV, et al. Genetics, 2000 Dec. PMID 11102369, Free PMC Article
    3. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Lemos B, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798037, Free PMC Article
    4. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
    5. Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity. Rahman M, et al. J Cell Biol, 2014 Jul 21. PMID 25023514, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    oxen
    Names
    CG8764-PA
    Ubiquinol-cytochrome C reductase
    Ubiquinol-cytochrome C reductase complex 7.2 kDa protein
    Ubiquinol-cytochrome c oxidoreductase 7.2 kDa
    Ubiquinol-cytochrome c reductase 7.2 kDa protein
    ox-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12757133..12757529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057637.5 → NP_476985.1  oxen [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XY35
      UniProtKB/TrEMBL
      A0A1B2AJQ1, Q8SY81
      Related
      FBpp0086974
      Conserved Domains (1) summary
      pfam05365
      Location:2 → 54
      UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY81 Q8SY81
    Q9XY35.1 Q9XY35

    Gene LinkOut

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