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    EAF7 Eaf7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EAF7
    Official Full Name
    Eaf7p
    Primary source
    SGD:S000005080
    Locus tag
    YNL136W
    See related
    AllianceGenome:SGD:S000005080; FungiDB:YNL136W; VEuPathDB:YNL136W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA repair and regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Orthologous to human MRGBP (MRG domain binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EAF7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (370368..371645)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene adenylate cyclase-binding protein Neighboring gene mitochondrial 37S ribosomal protein NAM9 Neighboring gene peptidylprolyl isomerase FPR1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction. Dalwadi U, et al. Mol Cell Biol, 2022 Nov 17. PMID 36190236, Free PMC Article
    2. NuA4 Lysine Acetyltransferase Complex Contributes to Phospholipid Homeostasis in Saccharomyces cerevisiae. Dacquay L, et al. G3 (Bethesda), 2017 Jun 7. PMID 28455416, Free PMC Article
    3. The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part. Miciałkiewicz A, et al. Acta Biochim Pol, 2008. PMID 18726008
    4. Deletion of host histone acetyltransferases and deacetylases strongly affects Agrobacterium-mediated transformation of Saccharomyces cerevisiae. Soltani J, et al. FEMS Microbiol Lett, 2009 Sep. PMID 19659745
    5. Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1. Kvas S, et al. BMC Genet, 2012 Mar 22. PMID 22439631, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro binding assays showed that Eaf3/5/7 specifically stimulates NuA4 binding to di- and trimethylated histone H3 Lys-36 and that this binding is important for NuA4 occupancy in transcribed ORFs.
      Title: The Eaf3/5/7 Subcomplex Stimulates NuA4 Interaction with Methylated Histone H3 Lys-36 and RNA Polymerase II.
    2. Eaf5 and Eaf7 form a subcomplex. Eaf7 interacts with NuA4 through Eaf5.
      Title: Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of H4/H2A histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eaf7p
    NP_014263.1
    • Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      370368..371645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182974.1 → NP_014263.1  TPA: Eaf7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014263.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W146, P53911
      UniProtKB/TrEMBL
      C7GKB1, G2WLX0, N1NXU8
      Conserved Domains (1) summary
      pfam07904
      Location:9 → 132
      Eaf7; Chromatin modification-related protein EAF7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53911.1

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