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    Ptr Patched-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35546, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ptrprovided by FlyBase
    Official Full Name
    Patched-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262867
    Locus tag
    Dmel_CG11212
    See related
    AllianceGenome:FB:FBgn0262867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11212; Dmel\CG11212; Dmptr; ptc-related-gene; ptr; Ptr_Dm
    Summary
    Predicted to be involved in cognition. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; epithelium; and head epidermis primordium. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Ptr in Genome Data Viewer
    Location:
    42A13-42A13; 2-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6181748..6196320, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2069253..2083825, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Asparagine-GTT 1-7 Neighboring gene transfer RNA:Asparagine-GTT 1-8 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit f2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel patched-related protein in Apis mellifera and Drosophila melanogaster. Pastenes L, et al. Arch Insect Biochem Physiol, 2008 Jul. PMID 18563713
    2. Spatial and temporal distribution of Patched-related protein in the Drosophila embryo. Bolatto C, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26506022
    3. Patched-Related Is Required for Proper Development of Embryonic Drosophila Nervous System. Bolatto C, et al. Front Neurosci, 2022. PMID 36081658, Free PMC Article
    4. The sterol-sensing domain: multiple families, a unique role? Kuwabara PE, et al. Trends Genet, 2002 Apr. PMID 11932020
    5. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Patched-related
    Names
    CG11212-PA
    CG11212-PB
    CG11212-PC
    CG11212-PD
    CG11212-PE
    Ptc related
    Ptc-related
    Ptc-related Disp-like
    Ptr-PA
    Ptr-PB
    Ptr-PC
    Ptr-PD
    Ptr-PE
    patched-related
    ptc-related gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6181748..6196320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259217.2 → NP_001246146.1  Patched-related, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    2. NM_001259216.2 → NP_001246145.1  Patched-related, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    3. NM_136365.3 → NP_610209.2  Patched-related, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Related
      FBpp0085347
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    4. NM_001273793.1 → NP_001260722.1  Patched-related, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KED8
      Conserved Domains (1) summary
      TIGR00917
      Location:12 → 89
      2A060601; Niemann-Pick C type protein family

    5. NM_001273794.1 → NP_001260723.1  Patched-related, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEC6
      Conserved Domains (1) summary
      TIGR00917
      Location:12 → 89
      2A060601; Niemann-Pick C type protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEC6 A0A0B4KEC6
    A0A0B4KED8 A0A0B4KED8
    Q86P36 Q86P36

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