nkd naked cuticle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nkdprovided by FlyBase
Official Full Name: naked cuticleprovided by FlyBase
Primary source: FLYBASE:FBgn0002945
Locus tag: Dmel_CG11614
See related: AllianceGenome:FB:FBgn0002945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11614; CG18224; Dmel\CG11614; naked; Nkd
Summary: Enables PDZ domain binding activity and zinc ion binding activity. Involved in neuroblast fate specification; regulation of canonical Wnt signaling pathway; and segment polarity determination. Located in cytosol and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; dorsal epidermis primordium; dorsal-ventral compartment boundary of the wing disc; head epidermis primordium; and imaginal disc. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1) and NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 75F2-75F4; 3-45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19003741..19045449, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18996841..19038549, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.
Title: Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.
Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker
Title: Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker.
Wingless signalling regulates the feedback antagonist naked cuticle through a series of Wingless response elements.
Title: Regulation of the feedback antagonist naked cuticle by Wingless signaling.
Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
Data suggest that Nkd acts at more than one subcellular location within signal-receiving cells to attenuate Wg signaling.
Title: Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd).
Nkd targets Dsh-dependent signal transduction steps in both cytoplasmic and nuclear compartments of cells receiving the Wnt signal.
Title: An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.
identification as a zinc-binding metalloprotein and role in antagonizing Wnt signalling via interaction with dishevelled
Title: Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0983 (e-PCR)
- UniSTS:75721

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed