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    SdhCL Succinate dehydrogenase, subunit C-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41324, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SdhCLprovided by FlyBase
    Official Full Name
    Succinate dehydrogenase, subunit C-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037860
    Locus tag
    Dmel_CG6629
    See related
    AllianceGenome:FB:FBgn0037860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6629; Dmel\CG6629
    Summary
    Predicted to enable electron transfer activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SdhCL in Genome Data Viewer
    Location:
    86D4-86D4; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11114671..11115706, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6940393..6941428, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45579 Neighboring gene UDP-glycosyltransferase family 35 member C1 Neighboring gene Mitochondrial aconitase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Drosophila melanogaster testis transcriptome. Vedelek V, et al. BMC Genomics, 2018 Sep 24. PMID 30249207, Free PMC Article
    2. Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster. Garlapow ME, et al. Behav Genet, 2017 Mar. PMID 27704301, Free PMC Article
    3. Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution. Bao R, et al. PeerJ, 2020. PMID 33083121, Free PMC Article
    4. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626, Free PMC Article
    5. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase, subunit C-like
    Names
    CG6629-PA
    SdhCL-PA
    NP_650041.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11114671..11115706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141784.2 → NP_650041.1  succinate dehydrogenase, subunit C-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650041.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGT9
      Related
      FBpp0081856, FBtr0082380
      Conserved Domains (1) summary
      cd03499
      Location:84 → 201
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGT9 Q9VGT9

    Gene LinkOut

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