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    PKD Protein Kinase D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42203, updated on 4-Jan-2025

    Summary

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    Official Symbol
    PKDprovided by FlyBase
    Official Full Name
    Protein Kinase Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038603
    Locus tag
    Dmel_CG7125
    See related
    AllianceGenome:FB:FBgn0038603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    150131_at; CG7125; Dmel\CG7125; dPKD; PKCm; pkd
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in adult brain; adult head; and adult mushroom body. Used to study candidiasis. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including PRKD1 (protein kinase D1) and PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See PKD in Genome Data Viewer
    Location:
    91A2-91A2; 3-63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18303279..18314407, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14129001..14140129, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit E Neighboring gene uncharacterized protein Neighboring gene nazgul Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constitutively active protein kinase D acts as negative regulator of the Slingshot-phosphatase in Drosophila. Nagel AC, et al. Hereditas, 2010 Oct. PMID 21039460
    2. Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. Ashe S, et al. Dev Biol, 2018 Feb 1. PMID 29247620
    3. Genetic interactions between Protein Kinase D and Lobe mutants during eye development of Drosophila melanogaster. Maier D, et al. Hereditas, 2019. PMID 31889943, Free PMC Article
    4. Maintenance of Rhodopsin levels in Drosophila photoreceptor and phototransduction requires Protein Kinase D. Ashe S, et al. Fly (Austin), 2018. PMID 30663936, Free PMC Article
    5. Calcium plays an essential role in early-stage dendrite injury detection and regeneration. Duarte VN, et al. Prog Neurobiol, 2024 Aug. PMID 38825174, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dPKD mediated secretion of dILP2 from neurosecretory cells during development is necessary for normal larval growth.
      Title: Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide.
    2. Data suggest that Drosophila protein kinase D is a multifunctional kinase involved in processes such as regulation of the cytoskeleton, cell proliferation and death as well as differentiation of various fly tissues.
      Title: Protein kinase D regulates several aspects of development in Drosophila melanogaster.
    3. Drosophila PKD may be multifunctional including a role in secretory transport in accordance with its subcellular distribution.
      Title: Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase D
    Names
    CG7125-PA
    CG7125-PB
    CG7125-PC
    CG7125-PD
    CG7125-PE
    CG7125-PF
    CG7125-PG
    CG7125-PH
    CG7125-PI
    PKD-PA
    PKD-PB
    PKD-PC
    PKD-PD
    PKD-PE
    PKD-PF
    PKD-PG
    PKD-PH
    PKD-PI
    NP_001138074.1
    NP_001262704.1
    NP_001262705.1
    NP_001262706.1
    NP_001262707.1
    NP_650710.3
    NP_732325.3
    NP_732326.3
    NP_732327.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18303279..18314407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142453.4 → NP_650710.3  protein kinase D, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Related
      FBpp0083010
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_001144602.2 → NP_001138074.1  protein kinase D, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. NM_169803.4 → NP_732325.3  protein kinase D, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Related
      FBpp0083011
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. NM_001275776.1 → NP_001262705.1  protein kinase D, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHC3
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. NM_001275775.1 → NP_001262704.1  protein kinase D, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    6. NM_169804.4 → NP_732326.3  protein kinase D, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Related
      FBpp0083012
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    7. NM_169805.4 → NP_732327.3  protein kinase D, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT87, Q9VE91
      Related
      FBpp0083013
      Conserved Domains (5) summary
      smart00109
      Location:223 → 272
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00220
      Location:547 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01239
      Location:396 → 522
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:539 → 798
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    8. NM_001275778.1 → NP_001262707.1  protein kinase D, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF0
      Conserved Domains (1) summary
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    9. NM_001275777.1 → NP_001262706.1  protein kinase D, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF0
      Conserved Domains (1) summary
      pfam00130
      Location:109 → 154
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGF0 A0A0B4KGF0
    A0A0B4KHC3 A0A0B4KHC3
    Q9VE91 Q9VE91

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