CG31140 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG31140provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0051140
Locus tag: Dmel_CG31140
See related: AllianceGenome:FB:FBgn0051140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13600; CG31452; CG5875; DGKt; Dmel\CG31140
Summary: Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; glycerolipid metabolic process; and protein kinase C signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95D1-95D4; 3-82 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23963180..23983232)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19788902..19808954)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerolipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein kinase C signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG31140-PA; CG31140-PB; CG31140-PD; CG31140-PE; CG31140-PF; CG31140-PG; CG31140-PH

NP_001097894.1

EC 2.7.1.107

NP_001097895.1

EC 2.7.1.107

NP_001247275.1

EC 2.7.1.107

NP_001262893.1

EC 2.7.1.107

NP_651199.2

EC 2.7.1.107

NP_996275.2

EC 2.7.1.107

NP_996276.1

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23963180..23983232

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206553.4 → NP_996276.1 uncharacterized protein Dmel_CG31140, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996276.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KS35

Conserved Domains (8) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:612 → 757

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:825 → 980

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:324 → 413

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:414 → 513

UBQ; Ubiquitin-like proteins

cl17169
Location:523 → 593

RRM_SF; RNA recognition motif (RRM) superfamily
NM_142942.6 → NP_651199.2 uncharacterized protein Dmel_CG31140, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651199.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VCF2

Related

FBpp0083885

Conserved Domains (8) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:1121 → 1266

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:1334 → 1489

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:833 → 922

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:923 → 1022

UBQ; Ubiquitin-like proteins

cl17169
Location:1032 → 1102

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001260346.1 → NP_001247275.1 uncharacterized protein Dmel_CG31140, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247275.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K716

Conserved Domains (8) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:1055 → 1200

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:1268 → 1423

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:767 → 856

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:857 → 956

UBQ; Ubiquitin-like proteins

cl17169
Location:966 → 1036

RRM_SF; RNA recognition motif (RRM) superfamily
NM_206552.4 → NP_996275.2 uncharacterized protein Dmel_CG31140, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996275.2

Status: REVIEWED

UniProtKB/TrEMBL

B5RJR9, Q7KS34

Conserved Domains (9) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:612 → 737

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:612 → 945

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:773 → 928

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:324 → 413

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:414 → 513

UBQ; Ubiquitin-like proteins

cl17169
Location:523 → 593

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001104424.3 → NP_001097894.1 uncharacterized protein Dmel_CG31140, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097894.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR94

Conserved Domains (8) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:1121 → 1266

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:1302 → 1457

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:833 → 922

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:923 → 1022

UBQ; Ubiquitin-like proteins

cl17169
Location:1032 → 1102

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001275964.1 → NP_001262893.1 uncharacterized protein Dmel_CG31140, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262893.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHZ4

Conserved Domains (8) summary

smart00109
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:1121 → 1266

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00609
Location:1302 → 1457

DAGK_acc; Diacylglycerol kinase accessory domain

pfam00788
Location:833 → 922

RA; Ras association (RalGDS/AF-6) domain

cl00155
Location:923 → 1022

UBQ; Ubiquitin-like proteins

cl17169
Location:1032 → 1102

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001104425.2 → NP_001097895.1 uncharacterized protein Dmel_CG31140, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097895.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86PB4

Conserved Domains (3) summary

cd00029
Location:6 → 55

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00130
Location:135 → 185

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl00040
Location:69 → 116

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K716		A0A0B4K716
A0A0B4KHZ4		A0A0B4KHZ4
A8JR94		A8JR94
Q7KS34		Q7KS34
Q7KS35		Q7KS35
Q86PB4		Q86PB4
Q95T86		Q95T86
Q9VCF2		Q9VCF2