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    LEA1 U2 snRNP complex subunit LEA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LEA1
    Official Full Name
    U2 snRNP complex subunit LEA1
    Primary source
    SGD:S000006134
    Locus tag
    YPL213W
    See related
    AllianceGenome:SGD:S000006134; FungiDB:YPL213W; VEuPathDB:YPL213W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable U2 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytoplasm. Part of U2 snRNP and U2-type prespliceosome. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LEA1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (150614..151330)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cbp3p Neighboring gene bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase Neighboring gene pseudouridine synthase PUS1 Neighboring gene ribosome biosynthesis protein NIP7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast U2A'/U2B complex is required for pre-spliceosome formation. Caspary F, et al. EMBO J, 1998 Nov 2. PMID 9799242, Free PMC Article
    2. The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae. Dix I, et al. RNA, 1999 Mar. PMID 10094305, Free PMC Article
    3. RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing. Moursy A, et al. Nat Commun, 2023 Nov 7. PMID 37935663, Free PMC Article
    4. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article
    5. Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Lacadie SA, et al. Mol Cell, 2005 Jul 1. PMID 15989965

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U2 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit LEA1
    NP_015111.1
    • Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      150614..151330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184027.1 → NP_015111.1  TPA: U2 snRNP complex subunit LEA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3F7, Q08963
      UniProtKB/TrEMBL
      A6ZW42, B3LKL7, B5VSW7, C7GN40, C8ZIG6, G2WNX2, N1P2L4
      Conserved Domains (2) summary
      COG4886
      Location:12 → 237
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:54 → 75
      LRR_1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08963.1

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