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    defl deflated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39141, updated on 27-Dec-2024

    Summary

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    Official Symbol
    deflprovided by FlyBase
    Official Full Name
    deflatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036038
    Locus tag
    Dmel_CG18176
    See related
    AllianceGenome:FB:FBgn0036038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18176; Dmel\CG18176; Int7; IntS7
    Summary
    Involved in snRNA 3'-end processing. Located in cytoplasm and nucleus. Part of integrator complex. Is expressed in embryonic/larval gut; larval central nervous system; and organism. Orthologous to human INTS7 (integrator complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See defl in Genome Data Viewer
    Location:
    67C5-67C5; 3-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9723423..9726706)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9716523..9719806)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nbs Neighboring gene N(alpha)-acetyltransferase 60 Neighboring gene ATP synthase, subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic analysis of deflated/Ints7 function in Drosophila development. Rutkowski RJ, et al. Dev Dyn, 2009 May. PMID 19326441
    2. Nucleosome organization in the Drosophila genome. Mavrich TN, et al. Nature, 2008 May 15. PMID 18408708, Free PMC Article
    3. Epigenetic telomere protection by Drosophila DNA damage response pathways. Oikemus SR, et al. PLoS Genet, 2006 May. PMID 16710445, Free PMC Article
    4. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    5. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deflated
    Names
    CG18176-PA
    defl-PA
    integrator 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9723423..9726706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140095.4 → NP_648352.2  deflated [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648352.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961P9, Q9VT41
      Related
      FBpp0076132
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT41.1 Q9VT41

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